Ozempic Side Effects: What are the Bad Side Effects of Ozempic

Ozempic is a prescription drug manufactured by Novo Nordisk. It was initially FDA-approved to help Type II diabetics control high blood sugar. This type of diabetes is caused by a person's inability to process glucose because of a lack of insulin.

If not treated, Type II diabetes can lead to severe physical conditions, including heart disease or stroke. Somewhat surprisingly, Ozempic users hoping to control their diabetes are reporting rapid weight loss. 

As a result, it's now relatively easy to find a healthcare professional who will prescribe Ozempic off-label as a weight loss aid rather than to improve blood sugar levels.

Before taking medications, patients need to know that they might cause serious allergic reactions. Most drug manufacturers must warn doctors and patients about the potential for a serious allergic reaction.

Unfortunately, many patients are now reporting some alarming, non-allergy side effects of Ozempic, primarily when used to lose weight.

The legal environment surrounding Ozempic continues to evolve. As of October 2024, over 1,000 cases have been consolidated in the Eastern District of Pennsylvania, alleging that Ozempic caused adverse effects such as gastroparesis, ileus, and vision loss.

Additionally, a recent settlement between Novo Nordisk and Mylan Pharmaceuticals concerning a patent dispute over Ozempic has been reached, although specific terms remain confidential.

Key Takeaway: Ozempic taken for weight loss can lead to serious side effects.

Despite being FDA-approved, studies have shown an increased risk of patients developing severe medical conditions after taking this prescription medication. Some of the worst potential Ozempic side effects may include:

• Stomach paralysis - which can lead to severe nausea, constipation, vomiting, and sudden or strong feelings of fullness
• Gallbladder issues
• Gallstones
• Pancreatitis
• Thyroid cancer
• Vision loss
• Kidney disease - or other related kidney problems
• Thoughts of suicide
• Other conditions that can cause severe pain

The team at Lawsuit Legal News is dedicated to providing the latest on the Ozempic lawsuit and up-to-date information about dangerous drugs and product liability lawsuits to keep you informed and help protect your legal rights. By following the latest news reports, we can answer the pressing question...

What are the bad side effects of Ozempic to watch out for?

First, How Does Ozempic Work?

Ozempic was created to help process sugar by acting as the hormone that increases insulin production in the body. The goal is to balance blood sugar levels by stopping excess sugar production in the liver while increasing insulin production in the pancreas.

Ozempic users receive a weekly injection of either 0.5 mg or 1mg. Over time, the dosage may be increased. Initially, many patients lost weight while using Ozempic, so doctors began prescribing the drug “off-label” for weight loss purposes, as we discuss below.

Potential Ozempic Side Effects When Taken For Weight Loss

The first of many observed side effects of Ozempic (generically known as Semaglutide) was weight loss. As a result, Novo Nordisk created Wegovy, which is explicitly prescribed for weight loss, not for treating Type II diabetes. 

When Ozempic was first introduced, the maker warned about some potential side effects, such as: 

• Pancreatitis - Inflammation of the pancreas
• Vision changes - related to nonarteritic anterior ischemic optic neuropathy (NAION)
• Kidney issues, including kidney failure
• Allergic reactions

Why Is Ozempic Bad For You?

Ozempic is not necessarily "bad for you," but it has sparked some controversy because of some of the dangerous side effects that have emerged from people taking the drug for weight loss and diabetes. 

Ozempic was created as a diabetic treatment, but it soon became popular as a weight loss drug. And like other weight loss drugs, it soon became evident that a shortcut to weight loss usually has consequences.

Some of the most common side effects of Ozempic that have caused severe injuries include increased risk of heart attack, bowel obstruction, gallstones, thyroid cancer, vision loss, and severe stomach paralysis.

Latest Side Effects of Ozempic

As time passes and more people are using these medications for weight management, we are realizing how dangerous they are. Here are some of the latest Ozempic side effects that users should be aware of:

1. Pregnancy-Related Issues

Recent findings indicate that Ozempic and similar drugs like Wegovy and Mounjaro can significantly reduce the effectiveness of birth control pills, potentially leading to unexpected pregnancies. This happens because these drugs can lower the concentration of contraceptive hormones in the blood by up to 66%.

2. NAION from Ozempic or other GLP-1 Medications

A recent study demonstrates that individuals who take Ozempic or Wegovy have an alarmingly high risk of developing NAION. This debilitating and permanent eye condition can result in irreversible blindness. 

NAION (Non-arteritic anterior ischemic optic neuropathy) is a disorder that impacts the optic nerve. It is caused by a lack of blood flow to the optic nerve. NAION is painless, can come on suddenly without warning, and is the second leading cause of blindness in adults behind glaucoma. 

A recent cohort study analyzed 16,827 individuals who used semaglutide. The rate of individuals who developed NAION from Ozempic was 8.9%, compared to 1.8% for the general population. 

Patients with Type 2 diabetes taking semaglutide had a fourfold higher risk of developing NAION, and those using it for weight loss had a sevenfold higher risk. Remember that this study only demonstrates an association, and further studies will be conducted to determine whether the link between Ozempic and NAION indicates causation or mere correlation.

We strongly recommend that anyone experiencing even minor vision problems after using Ozempic or Wegovy immediately consult with a health care professional.

3. Gastroparesis and Gastrointestinal Issues

Gastroparesis, a severe condition causing delayed stomach emptying, is one of the most serious side effects linked to Ozempic. This condition can lead to symptoms like nausea, vomiting, bloating, and severe dehydration. In addition to gastroparesis, the most common gastrointestinal side effects include nausea, constipation, and diarrhea​.

Novo Nordisk (manufacturer of Ozempic and Wegovy) and Eli Lilly (manufacturer of Mounjaro) have yet to change their warning label to reference the risk of gastroparesis despite the number of adverse event reports obtained by the FDA. 

While Ozempic may significantly improve blood sugar markers, it has been linked to several gastrointestinal issues. The most common adverse reactions to semaglutide are gastrointestinal issues, including gastroparesis, intestinal blockage, and ileus. In fact, ileus, gastroparesis, and intestinal blockage are the most common side effects associated with weight loss drugs like Ozempic and Wegovy.

Ileus, gastroparesis, and intestinal blockage are the most common side effects associated with weight loss drugs like Ozempic and Wegovy.

4. Deep Vein Thrombosis or Other Blood Clots

A study published in Endocrine Journal, Comprehensive analysis of the safety of semaglutide in type 2 diabetes: a meta-analysis of the SUSTAIN and PIONEER trials, linked Ozempic to blood clots, including pulmonary embolism and deep vein thrombosis (DVT). Individuals using Ozempic demonstrated a 266% increased risk of DVT.

Deep vein thrombosis (DVT) occurs when a blood clot forms in one of the deep veins in the body, usually in the legs. What makes a DVT particularly dangerous is when the blood clot breaks off and travels through the body. 

If the clot travels through the bloodstream and gets stuck in the lungs, it can block blood flow. This is known as a pulmonary embolism. We are investigating many Ozempic blood clot claims along with Ozempic DVT claims.

5. Physical Changes Including "Ozempic Face" and Sagging Skin

Rapid weight loss associated with Ozempic can lead to sagging skin in various body parts, commonly referred to as "Ozempic face" or "Ozempic neck." This occurs due to losing muscle mass and fat, leading to loose skin.​ Other physical changes under review include hair loss.​

6. Low Blood Sugar

Ozempic and Wegovy can cause hypoglycemia (low blood sugar) in individuals who use semaglutide in conjunction with other diabetic medications, such as insulin. 

7. Serious Allergic Reaction

There is only anecdotal evidence to date of severe allergic reactions following semaglutide use. However, please seek medical attention immediately if you develop a rash or experience difficulty breathing. 

These updates highlight the importance of users closely monitoring and consulting with healthcare providers, particularly for off-label uses such as weight loss. For more detailed information, refer to sources like Drugwatch and recent publications in JAMA Ophthalmology.

8. Serious Allergic Reaction

There is only anecdotal evidence to date of serious allergic reactions following semaglutide use. However, please seek medical attention immediately if you develop a rash or experience difficulty breathing. 

These updates highlight the importance of users closely monitoring and consulting with healthcare providers, particularly for off-label uses such as weight loss. For more detailed information, refer to sources like Drugwatch and recent publications in JAMA Ophthalmology.

9. Diabetic Retinopathy

Diabetic retinopathy is a complication of diabetes that affects the eye and overall eyesight. While Ozempic may be used to help treat diabetes-related obesity, anecdotal evidence demonstrates that semaglutide may exacerbate diabetic retinopathy. While Ozempic may significantly reduce body weight, the risk to your vision isn't worth the trade-off.

10. Suicidal Thoughts and Mental Health Concerns

Recently, there have been reports linking the use of semaglutide, the active ingredient in Ozempic, to suicidal thoughts and behaviors. A study published in JAMA highlighted this potential side effect, particularly among users who were also taking antidepressants or anti-anxiety medications. This finding has prompted further investigation into the mental health risks associated with semaglutide. It's important to be aware of this potential side effect, especially if you or someone you know is considering or currently using Ozempic for diabetes management or weight loss.

Key Takeaways

• What Was Studied? The study looked at whether two popular drugs, semaglutide (Ozempic) and liraglutide, which are used for type 2 diabetes and weight loss, are linked to an increased risk of suicidal thoughts.
• Findings: There is some evidence suggesting that semaglutide may be associated with an increased risk of suicidal thoughts, especially in people already taking antidepressants or anti-anxiety medications. However, this link wasn’t found with liraglutide.
• What Does This Mean? While the findings are concerning, more research is needed to understand whether semaglutide indeed increases the risk of suicidal thoughts or if other factors might be involved.

Background

Semaglutide and liraglutide are medications often prescribed to help with weight loss, in addition to managing type 2 diabetes. They have become quite popular, partly due to their effectiveness in assisting people to lose weight. However, as these drugs have become more widely used, concerns have emerged about potential side effects, including mental health issues.

The Study

Researchers used data from the World Health Organization (WHO) to examine reports of suicidal thoughts and behaviors in people taking these drugs. They compared these reports to those from people taking other medications, including other diabetes and weight loss drugs like metformin and orlistat.

What Did They Find?

• Semaglutide: There was a noticeable increase in reports of suicidal thoughts among people taking semaglutide, especially those who were also on antidepressants or anti-anxiety medications.
• Liraglutide: The same increase was not seen with liraglutide.
• Severity: The study did not find many cases where these thoughts led to suicide, but the increase in suicidal thoughts was significant enough to cause concern.

Limitations

• Not Definitive: The study can't prove that semaglutide causes suicidal thoughts; it only shows that these thoughts were reported more often in people taking the drug.
• Other Factors: Many people taking semaglutide were also dealing with other mental health issues, which could have contributed to the increase in suicidal thoughts.
• More Research Needed: More detailed studies, especially ones that track people over time, are needed to fully understand the risks.

What Should Consumers Do?

If you or someone you know is taking semaglutide (or considering it), it's important to monitor for any changes in mood or behavior. If you notice any signs of depression or suicidal thoughts, contact a healthcare professional immediately. This study highlights the need for caution but does not suggest that everyone should stop using the drug.

Conclusion

While semaglutide has been effective for many in managing diabetes and aiding weight loss, the potential link to suicidal thoughts is something to take seriously. Anyone using the drug should stay informed and consult with their doctor to weigh the benefits and risks.

11. Potential Bone Health Risks Linked to Ozempic

A recent study from JAMA Network Open has raised concerns about the effects of GLP-1 receptor agonists, such as Ozempic (semaglutide), on bone mineral density. GLP-1 receptor agonists are widely used for diabetes management and weight loss. Still, findings suggest that while these medications effectively induce weight loss, they may also reduce bone density, particularly in the hip and spine. This could increase the risk of fractures in patients undergoing treatment.

The study showed that combining exercise with GLP-1 receptor agonist treatment helped preserve bone health, highlighting the need for a more comprehensive approach to weight loss that includes physical activity. Without exercise, the GLP-1 receptor agonist group experienced notable decreases in bone mineral density despite weight loss benefits.

As the use of these drugs continues to grow, there is an emerging concern about the long-term side effects, particularly for individuals at higher risk of osteoporosis or bone fractures. This opens the door for potential litigation surrounding product liability claims if patients experience adverse bone-related events while taking these medications.

If more evidence continues to link GLP-1 receptor agonists to bone health deterioration, we may see an increase in lawsuits related to fracture risks, similar to other long-term drug side-effect cases.

The First Reported Bad Side Effect of Ozempic: Gallbladder Problems

From the start, Ozempic users have reported experiencing gallstones, biliary diseases, and acute gallbladder disease after taking the drug. Researchers think Ozempic may increase cholesterol production, forcing the gallbladder to create more bile to break down excess cholesterol.

If cholesterol is too high, the gallbladder can't control it, and the cholesterol forms hard deposits called gallstones.

Some small gallstones may dissolve or pass naturally through the body, but with too many gallstones or a large gallstone that won't pass, the person may require medical intervention.

For example, they may develop Cholecystitis if a gallstone or group of gallstones block the bile duct and prevent the release of bile. This condition is often only resolved through surgery.

An extensive analysis of clinical trials involving Ozempic users was performed. The results indicated an increased risk of gallbladder problems suffered by Ozempic users who used the medication:

• For weight loss purposes
• In high doses or 
• Over a prolonged time

According to Ozempic’s warning labels, clinical studies revealed that a dose of 0.5 mg caused Cholelithiasis in 1.5% of participants, while a 1 mg dose caused Cholelithiasis in 0.4%. A shocking 90 percent of the people who developed these gallbladder problems needed surgery to remove their gallbladders altogether—notably, none of the study participants who received a placebo injection suffered from Cholelithiasis gallstones.

A shocking 90 percent of the people who developed these gallbladder problems needed surgery to remove their gallbladders altogether. Significantly, none of the study participants who received a placebo injection suffered from Cholelithiasis gallstones.

Read more about the Ozempic Gallstone Lawsuit or Speak to an Ozempic Gallstone Lawyer

Soon, Patients Reported Another Terrible Side Effect of Ozempic: Stomach Paralysis

When someone takes Ozempic, they feel more full for longer because the drug slows down how quickly food leaves their stomach. These people have fewer urges to eat because the drug also controls a hormone that makes them feel hungry. Without the desire to eat, and when they feel full, people are likelier to eat less and lose weight.

However, these Ozempic side effects can be dangerous. Studies have shown that Ozempic impacts the stomach’s nerves, affecting the rate of digestion and sometimes slowing the process too much. If food stays in the stomach for too long, it can form a solid mass that can lead to nausea, cramping, and vomiting of food eaten several days earlier.

If food stays in the stomach for too long, it can form a solid mass that can lead to nausea, cramping, and vomiting of food eaten several days earlier.

The stomach becomes paralyzed when the stomach muscles slow too much or stop completely. This condition is called gastroparesis. Sufferers describe ongoing nausea, acid reflux, pain in the stomach and intestines, fullness after small amounts of food, and lack of appetite. 

Now We Know About Even More Bad Ozempic Side Effects to Look For

In an article by MSN.com, a doctor described several other potential side effects of Ozempic. Some of the other possible bad side effects Ozempic users may experience include:

• Sarcopenia - the loss of muscle mass
• Excess stomach air or gas
• Heartburn
• Burping
• Indigestion
• Fast heart rate
• Low energy
• Low blood sugar
• Fatigue

Other severe but less common Ozempic side effects may include:

• Pancreatitis
• Appendicitis
• Thyroid cancer
• Decreased kidney function
• Anaphylaxis - a severe allergic reaction that can be life-threatening
• Angioedema - a swelling under the skin
• NAION vision loss - which can cause permanent vision loss or blindness

What Should You Do If You Experience These Serious Ozempic Side Effects?

First, if you have any serious medical concerns after taking any medications, contact your doctor to discuss your options. Explain your symptoms and problems in detail so your doctor can help create the best treatment plan for your unique circumstances.

Next, talk to an experienced dangerous drug lawyer. If you suffer financial or other losses as a result of taking Ozempic, you may be eligible to bring an Ozempic lawsuit against Novo Nordisk or other entities that are responsible for your condition and damages. 

A knowledgeable Ozempic gallbladder attorney or Ozempic stomach paralysis lawyer can review your situation and answer any questions you may have about your legal rights. The legal professionals affiliated with Lawsuit Legal News offer free consultations to help you determine your best course of action.

Trust Lawsuit Legal News to Explain the Bad Ozempic Side Effects You Might Experience and Your Legal Rights

When an innocent consumer is prescribed a drug to help treat a condition, they have the right to believe the drug won't harm them. Or, if there are known dangerous side effects, the drug maker must warn users about the potential dangers so they can make an informed decision before they take the drug. 

If you have any of the severe side effects of Ozempic discussed in this post, you might be able to hold the drug manufacturer responsible for your financial losses, pain, and suffering. 

Contact the Lawsuit Legal News team of mass tort lawyers for answers. Complete our online contact form for a free consultation today.

Frequently Asked Questions about Ozempic's Bad Side Effects

Below are answers to some of your most common questions about Ozempic's harmful side effects.

Can Ozempic Cause High Cholesterol?

Ozempic works by increasing insulin secretion, decreasing glucagon release, and slowing gastric emptying, thereby helping to control blood sugar levels.

These functions do not typically cause cholesterol problems; therefore, Ozempic is not generally associated with causing high cholesterol. Clinical studies have shown that Ozempic can have beneficial effects on lipid profiles. Patients using Ozempic often experience:

• Reduction in LDL cholesterol (bad cholesterol)
• Increase in HDL cholesterol (good cholesterol)
• Decrease in triglycerides

These so-called "good" side effects of Ozempic are most likely due to the rapid weight loss, which improves cholesterol panels.

However, individuals' responses to Ozempic can vary. While many people experience improved cholesterol, some might not see significant changes. Additionally, patients with other health conditions, such as hypothyroidism or metabolic syndrome, might experience problems with their cholesterol levels while on Ozempic.

Other medications taken alongside Ozempic can also affect cholesterol levels, which is why it's so important to involve your healthcare provider in every decision you make regarding your health and which medications you are taking.

If you have concerns about your cholesterol levels while taking Ozempic, speak to your doctor directly.

Can Ozempic Cause Appendicitis?

There is limited evidence to suggest a direct link between Ozempic and the development of appendicitis. However, some gastrointestinal side effects associated with Ozempic might mimic or potentially worsen conditions that could lead to appendicitis.

Appendicitis is an inflammation of the appendix, typically caused by an obstruction or infection. Symptoms include abdominal pain, particularly around the lower right abdomen, nausea, vomiting, loss of appetite, fever, and constipation or diarrhea. 

Ozempic can cause these same side effects, making it critical to differentiate between side effects caused by Ozempic and signs of appendicitis.

If you are taking Ozempic and experience severe abdominal pain—especially if it is localized to the lower right side—accompanied by fever, nausea, or vomiting, it is crucial to seek medical attention right away.

What Are The Downsides of Ozempic?

Ozempic (semaglutide) is an effective medication for managing type 2 diabetes, but it comes with potential downsides and side effects. Here are some of the key drawbacks associated with its use:

Common Side Effects of Ozempic

• Gastrointestinal Issues: Many patients experience gastrointestinal side effects such as nausea, vomiting, diarrhea, constipation, and abdominal pain. These side effects are usually mild to moderate and decrease over time as the body adjusts to the medication.
• Appetite Changes: While the reduction in appetite can benefit weight loss, it may also lead to unintended weight loss or malnutrition if not adequately managed.

Serious Side Effects

• Pancreatitis: There have been reports of acute pancreatitis (inflammation of the pancreas) in patients taking GLP-1 receptor agonists like Ozempic. Symptoms include severe abdominal pain, nausea, and vomiting, and require immediate medical attention.
• Gallbladder Disease: Ozempic may increase the risk of gallbladder disease, including gallstones. Symptoms can include severe abdominal pain, fever, and jaundice.
• Kidney Problems: Some patients, particularly those with pre-existing kidney conditions, might experience worsening kidney function. Symptoms can include changes in urine output and swelling in the legs or feet.

Long-Term Risks

• Thyroid Tumors: In animal studies, semaglutide has been shown to cause thyroid C-cell tumors. Although this risk has not been confirmed in humans, it is a potential concern, especially for those with a family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. There is a warning that Ozempic use has been linked to thyroid cancer.
• Cardiovascular Issues: While Ozempic can have positive effects on cardiovascular health, such as lowering blood pressure and improving lipid profiles, long-term studies are still needed to fully understand its impact on heart health.

Other Negative Side Effects of Ozempic

• Hypoglycemia: When used in combination with other diabetes medications, particularly insulin or sulfonylureas, Ozempic can increase the risk of hypoglycemia (low blood sugar). Symptoms of hypoglycemia include dizziness, sweating, confusion, and fainting.
• Injection Site Reactions: Some patients may experience pain, redness, or irritation at the injection site.

Some patients might experience more severe side effects, while others might tolerate the medication with minimal issues. To manage potential risks properly, it's important to monitor yourself for any adverse effects and speak to your doctor routinely while taking Ozempic.

How Serious Is Gastroparesis?

Gastroparesis is a serious condition, potentially life-threatening condition where the stomach cannot empty properly, leading to nausea, vomiting, and nutritional deficiencies. 

It can significantly impact quality of life and may require dietary changes, medications, or surgery to manage symptoms and prevent complications. It is so common and serious, in fact, that it even has its own awareness month in August.